A MULTICENTRE RANDOMISED CONTROLLED TRIAL
Understanding lung
recruitability.
Personalising ventilation.
EITVent-2 investigates whether EIT-guided PEEP improves outcomes in moderate-to-severe ARDS, and whether its effects differ by lung recruitability.
for individualised ventilation in ARDS
THE SCIENTIFIC QUESTION
One clinical syndrome.
Different responses to PEEP.
Acute respiratory distress syndrome brings together patients with different patterns of lung injury. The same positive end-expiratory pressure (PEEP) may not offer the same balance between alveolar collapse and overdistension for every patient.
Electrical impedance tomography (EIT) provides real-time, radiation-free information at the bedside. EITVent-2 uses this information to study lung recruitability and evaluate an individualised approach to PEEP.
Whether this strategy improves clinical outcomes remains a research question.
Bedside EIT assessment
Assess regional collapse
before randomisationStratified randomisation
Compare two PEEP strategies
with 1:1 allocationClinical outcomes
Evaluate day-28 mortality
and follow-up to day 60
EITVENT-2 NETWORK
Bring your centre into EITVent-2.
Review the preparation checklist and connect with the research team about centre participation.